Topic: Nandrolone False Positives

[Michael Hartman]

To my knowledge there is no way to determine endogenous nandrolone metabolites from exogenous. The British Journal of Sports Medicine did a review a few years back on the probability of a nandrolone false positive.  They confirmed that nandrolone can be prsent in urine under several conditions including stressful exercise, in dehydrated conditions, and following traumatic stress (i.e. musculoskeletal injury).  They basically suggest that the IOC raise the cut-off from 2 ng/ml in men and 5 ng/ml in women.  I also wonder if the IOC takes any of this research into account when doing doping tests following competition, which typically includes stressful exercise, dehydration, and traumatic stress.

[glennpendlay]

wasnt there something in one of the studies done on this that showed large meet consumption could also lead to over the limit amounts in the body?  for some crazy reason, im thinking that the study was done using horse meat...  but i might be way off on this.  of course this would mean that it would have had to be done outside the US...

[Michael Hartman]

There was some work done by a German scientist that confirmed eating meat that had been treated with anabolic hormones could lead to a false positive.  I don't think it was horse meat, but you never know.

Debruyckere G, Van Peteghem CH. Influence of the consumption of meat contaminated with anabolic steroids on doping tests. Analytica Chimica Acta 1993;275:49–56.

[glennpendlay]

well, maybe my desire to finally find out just how tasty horse meat really is has gotten the best of me.

[Dean Redzic]

ABSTRACT
SCHMITT, N., M. M. FLAMENT, C. GOUBAULT, P. LEGROS, M. F. GRENIER-LOUSTALOT, and A. DENJEAN. Nandrolone
excretion is not increased by exhaustive exercise in trained athletes. Med. Sci. Sports Exerc., Vol. 34, No. 9, pp. 1436–1439, 2002.
Purpose: The anabolic steroid nandrolone is widely used as a performance enhancer. Traces of its naturally occurring metabolite
19-norandrosterone (19-NA) have been found in human urine (below 0.6 ng·mL
1), and it has been suggested that strenuous exercise
may increase urinary 19-NA. The aim of our study was to assess the effect of exhaustive exercise on the nandrolone excretion under
controlled conditions in two groups of trained male athletes, one composed of judoka and the other of long-distance runners. Methods:
A Wingate test and a treadmill limited-time test (running at 85% V˙ O2max) were carried out on 14 judoka and 15 athletes. Hydration
was controlled during each session. Urine samples were obtained before each test and 30 min, 60 min, and 24 h after each test. Urinary
19-NA concentrations were determined using gas chromatography coupled with mass spectrometry. Results: Baseline urinary 19-NA
concentrations varied widely across individuals, from undetectable levels to 0.250 ng·mL
1 (mean, 0.048  0.050 ng·mL
1). The both
exercise tests did not significantly modified urinary 19-NA levels in the two groups of subjects. Conclusion: Our study provides
compelling evidence that endogenous nandrolone production in male athletes, during two very different types of exercise, produces
urine levels far below the IOC threshold of 2 ng·mL
1 urine. Thus, exercise does not induce endogenous nandrolone secretion.

[Dean Redzic]

I love mortadella...which is a processed meat, made of horse...mmmm.


I dont know what The US is like, but in australia any animal that can be ingested or produces milk or eggs has a clearance time for their drug injections. For example if you produce bacon, your pigs must have 21 days between steroid injection and time of killing.

[ButchCurry]

Nandrolone excretion is not increased by exhaustive exercise in trained athletes...  
 
Thus, exercise does not induce endogenous nandrolone  excretion.

 
I CAN'T believe the final part of this quote! In the title, the Authors use the word "exhaustive". To me, this implies a certain type of exercise, but certainly not all. Yet their final statement leaves out any qualifier of the exercise and makes a blanket statement. The implication is that NO exercise can cause this, but that's not what they tested for. I'm surprised this passed peer review.
 
Now, maybe if they did some anaerobic type workout, like maybe an Olympic Lifting session, they can add to that statement. But to me, this abstract's conclusion is anything but conclusive.
 

[Dean Redzic]

I was using it as part of an assignment, i havent looked for any anaerobic based studies(since my assignment didnt call for this, i will look in a couple days)

Its a real bad study. But a few basic changes to the wording could fix that. Even the title of the article is cocky:Nandrolone
excretion is not increased by exhaustive exercise in trained athletes.
It could have easiely be named: Excretion of Nandrolone durin
aerobic exercise in trained athletes.

Any way some food for thought